Upper Island Cove is located about 110km from the capital city of St. John's off Route 70, the Conception Bay Highway, between the towns of Harbour Grace and Spaniard's Bay. There are three entrances / exits to the town from Route 70: one through “the Thicket Road” between Harbour Grace and Tilton and two entrances from Spaniard’s Bay: one through the scenic Bishop’s Cove Shoreline and the other through Crane’s Road.